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KMID : 0386720080200040320
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Journal of the Korean Hip Society
2008 Volume.20 No. 4 p.320 ~ p.325
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The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis
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Chung Whan-Young
Lee Woo-Suk
Kim Sang-Bum
Bae In-Tak
Park Won-Ki
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Abstract
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Purpose: The aim of this study was to evaluate the expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).
Materials and Methods: We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF.
Results: The chondrocytes of the AVN group showed decreased expressions of type Ⅱ collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).
Conclusion: The cartilage matrix’s formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.
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KEYWORD
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Avacular necrosis, Chondrocytes, Type Ⅱ collagen, Aggrecan, VEGF-A, PEDF
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